The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo
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چکیده
منابع مشابه
The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo.
At the peripheral neuromuscular junction (NMJ), a significant number of nicotinic acetylcholine receptors (AChRs) recycle back into the postsynaptic membrane after internalization to intermingle with not-yet-internalized ;pre-existing' AChRs. However, the way in which these receptor pools are maintained and regulated at the NMJ in living animals remains unknown. Here, we demonstrate that recycl...
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The majority of acetylcholine receptors (AChRs) at normally innervated neuromuscular junctions are stable, with a half-life averaging about 12 d in most rodent muscles. Following denervation, the AChRs turn over much more rapidly after a lag period. The mechanism by which motor nerves normally maintain stabilization of junctional AChRs is not yet known. In order to determine whether synaptic tr...
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The pharmacodynamics profile of a drug plays an important role in the development of a novel therapeutic agent. The above mentioned basic foundation is also applicable to the development of drugs which are directed towards the neuromuscular junction. The nicotinic acetyl choline receptor has been predominant role at the neuromuscular junction and has minor role in the central nervous system. Th...
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ژورنال
عنوان ژورنال: Development
سال: 2006
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.02619